4-star boutique hotel in the Prati district, a short walk from Castel Sant'Angelo, with a Roman restaurant and rooftop terrace offering panoramic breakfast views over Rome.
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Twentyone Hotel is a 4-star boutique hotel located on Via Cola di Rienzo, in the Prati district of Rome, about a 10-minute walk from Castel Sant’Angelo and the historic center. The building stands out for its minimalist, contemporary design, which characterizes both the common areas and the rooms.
The rooms, all air-conditioned, are furnished with modern lines and equipped with satellite LCD TV, minibar and free WiFi; some higher categories offer a balcony, private terrace or hydromassage tub, while the family solutions accommodate up to four people. In the morning, buffet breakfast is served in the panoramic rooftop room, with views over the city, while the in-house restaurant serves traditional Roman and Italian dishes accompanied by a selection of wines and champagne. A Starbucks coffee shop is also located inside the property.
The location in the Prati district makes it possible to reach the Vatican and St. Peter’s Basilica on foot in about 15 minutes, while Lepanto metro station is a few hundred meters away. A good choice for those wanting to explore Rome through shopping, history and gastronomy, with quick connections to the city center.
Twentyone Hotel offers eight room types, all air-conditioned, soundproofed and equipped with a private bathroom, flat-screen TV, minibar and free WiFi connection, in line with the minimalist style that characterizes the entire property. Room sizes range from 18 to 29 square meters, offering solutions suited to both couples and families or small groups, with double bed or twin bed configurations.
Some rooms stand out for specific details: the Deluxe Double Room and the Deluxe Twin Room have a balcony, in some cases with a view of St. Peter’s Basilica, while the Superior Double Room features a round bed and a hydromassage tub with complimentary bathrobes. The Family Room, the largest in the range, accommodates up to four people and still includes bathrobes and slippers, confirming the attention to small details across every category.
The Double Room is the most compact option in the property, with 18 square meters designed for a simple stay as a couple. Equipped with LCD TV, minibar and air conditioning, it offers a tidy and functional environment, ideal for those looking for a practical base to explore Rome without giving up basic comfort.
Larger than the standard Double Room, this 23-square-meter room stands out for its private balcony, from which some units offer a glimpse of St. Peter’s Basilica. A good balance between space and view for couples wanting a bit more room.
Designed for parties of three, this 22-square-meter room is furnished with three single beds, while maintaining the same air-conditioning and technology standards as the other room types. A practical choice for groups of friends or small families.
The only room in the property with a round bed and a hydromassage bathtub, made even more special with complimentary bathrobes and slippers. A space designed for those seeking a more refined touch during their stay, clearly distinguishing itself from the other double room options.
The most spacious room in the property, at 29 square meters, with a flexible configuration combining single beds and a double bed, suited to families or small groups of up to four people. It includes complimentary bathrobes and slippers, an uncommon detail among the more affordable room types.
With the same size as the Deluxe Double Room but configured with two single beds, this room has a private balcony, ideal for two travelers who prefer separate beds.
The most compact version with single beds, at 18 square meters, designed for a functional stay without a balcony or view, but with all the essential comforts of the property.
Twentyone Hotel offers a range of services designed for a comfortable urban stay, starting with the 24-hour front desk and concierge service, useful for organizing city tours and excursions. Attention to accessibility is also present, with wheelchair access, rooms for guests with disabilities and an elevator to the upper floors.
On the dining side, the property offers an in-house restaurant, a bar, room service and the option to have breakfast in your room, as well as an on-site coffee shop. For guests traveling with children, dedicated meals and a children’s buffet are available.
Among the general services are the gym, terrace and garden, laundry and ironing service, luggage storage and shuttle service. All rooms feature air conditioning, soundproofing and free WiFi connection, rounding out an offering geared toward both relaxation and practicality.
Twentyone Hotel is located on Via Cola di Rienzo, a shopping street in the Prati district, one of Rome’s most elegant and livable neighborhoods, just steps from shops, cafés and restaurants such as Eros and Pazzi di Pizza, both less than 30 meters from the property. The area retains a residential, upscale character, while still being within walking distance of the city’s main landmarks.
Lepanto metro station is 350 meters away, while Flaminio station is about 700 meters away; Roma San Pietro railway station is 1.9 km away. Castel Sant’Angelo can be reached in about 700 meters, Piazza del Popolo in 600 meters and St. Peter’s Square in 1.2 km, as can the Vatican Museums, at 1.3 km. For those arriving by air, Fiumicino Airport is about 18 km away, and Ciampino Airport is 14 km away.
From here, both the Vatican and the historic center can be reached on foot in just over a quarter of an hour, with Piazza Navona 700 meters away and the Trevi Fountain 1.5 km away. The area is well suited to evening walks along the Tiber, morning visits to the Vatican museums and shopping on Via Cola di Rienzo, while in spring and summer the nearby Pincio, 750 meters away, offers a pleasant green view above Piazza del Popolo.
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Guests especially praise the location, rated 9.3, and the staff, with a score of 8.8. Cleanliness and comfort remain at solid levels (8.6), while the value for money, although positive, is the slightly weaker point of the overall assessment.
Rates at Twentyone Hotel vary depending on the season, room type and dates of stay. You can check the updated price from our search partners.
No, Twentyone Hotel does not allow pets during the stay.
Yes, Twentyone Hotel offers a private garage, but spaces are limited and subject to availability.
Twentyone Hotel is about a 15-minute walk from the Vatican and St. Peter’s Basilica, and 1.3 km from the Vatican Museums.
Yes, Twentyone Hotel provides free WiFi connection in all rooms and common areas.
Twentyone Hotel offers a continental and American buffet breakfast, served in a rooftop room with city views.
Yes, Lepanto metro station is about 350 meters from Twentyone Hotel.
